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Effects of vincristine (VCR) and cytochalasin B (CYB) on FTI-induced morphological changes of KNRK cells. KNRK cells were pretreated with DMSO (A and B) or with 2.1 μM CYB (C) or with 1.2 nM VCR (D). After 24 h, cells were treated with 20 μM SCH56582 for 24 h. (A) KNRK. (B) KNRK treated with SCH56582. (C) KNRK treated with SCH56582 and CYB. (D) KNRK treated with SCH56582 and VCR. At least three experiments were carried out with results similar to those shown here.
