Table II.
Genotyping distribution of PTPN13 SNPs of SCCHN cases and cancer-free controls and their association with SCCHN risk
| SNP position | Cases, n (%) | Controls, n (%) | P value | Crude OR (95% CI) | Adjusted OR (95% CI)a |
| All subjects | 1069 (100.0) | 1102 (100.0) | |||
| c.4068 T>G F1356L (rs10033029) | 0.326b | ||||
| TT | 815 (76.2) | 857 (77.8) | 1.00 | 1.00 | |
| GT | 239 (22.4) | 223 (20.2) | 1.13 (0.92–1.39) | 1.09 (0.88–1.35) | |
| GG | 15 (1.4) | 22 (2.0) | 0.72 (0.37–1.39) | 0.61 (0.31–1.22) | |
| G allele | 0.126 | 0.121 | 0.640c | ||
| c.4566 A>G I1522M (rs2230600) | 0.001b | ||||
| AA | 695 (65.0) | 747 (67.8) | 1.00 | 1.00 | |
| AG | 290 (27.1) | 310 (28.1) | 1.01 (0.83–1.22) | 1.00 (0.82–1.22) | |
| GG | 84 (7.9) | 45 (4.1) | 2.01 (1.38–2.92) | 1.89 (1.27–2.79) | |
| G allele | 0.214 | 0.182 | 0.007c | ||
| c.6241 T>G Y2081D (rs989902) | 0.014b | ||||
| TT | 332 (31.1) | 392 (35.6) | 1.00 | 1.00 | |
| GT | 572 (53.5) | 524 (47.6) | 1.29 (1.07–1.56) | 1.26 (1.03–1.53) | |
| GG | 165 (15.4) | 186 (16.9) | 1.05 (0.81–1.35) | 1.00 (0.76–1.30) | |
| G allele | 0.422 | 0.407 | 0.304c |
a
Adjusted for age, sex, smoking and drinking status in the logistic regression model.
b
Distribution of three genotypes.
c
Test for allele differences between cases and controls.