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Molecular modes of GR action. GCs passively diffuse into the cell and bind to the GR (1). This results in the dissociation of the heat shock protein complex (Hsps) (2) and translocation of the ligand-bound GR into the nucleus. There the GR modulates transcription either by binding to DNA (3) or via interaction with other transcription factors (4). Non-genomic mechanisms of GR action include interference with cytosolic signaling molecules (5).
