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The role of GCs in thymocyte development. At the double-positive (DP) stage developing thymocytes undergo positive and negative selection which is controlled by an interplay between GR- and T cell receptor (TCR)-derived signals. Mature single-positive (SP) thymocytes are protected from GC-induced apoptosis by CD28 signaling. cTEC, cortical thymic epithelial cell; DC, dendritic cells; mTEC, medullary thymic epithelial cell.
