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Sequence alignment of TPH2 and PAH in human. Coding synonymous and coding non-synonymous mutations in human TPH2 are shown with arrows. The coding non-synonymous mutation in mouse Tph2 is shown with an arrowhead. PAH mutations that affect substrate binding, protein folding and BH4 binding are indicated with filled boxes, closed circles and open circles, respectively (gene accession numbers: NM_173353 [TPH2], NM_000277 [PAH]).
