TABLE 5.

ANALGESIC ACTIVITY OF THIAZOLIDINONES IN ACETIC ACID-INDUCED WRITHING IN MICE AND RAT CAUDAL IMMERSION

Compound code	Dose (mg/kg)	Writhing response	Percentage inhibition	Caudal immersion reaction time (In sec.)
Control	50	36.00±0.70	0.0	1.05±0.022
Nimesulide	50	14.50±0.64**	59.8	4.05±0.010
B1	50	22.50±0.86**	37.5	1.90±0.02
	100	20.00±1.58**	44.5	1.85±0.08
B2	50	20.00±1.87**	44.5	1.70±0.04
	100	16.75±1.31**	53.5	1.72±0.02
B3	50	20.25±1.43**	43.8	1.60±0.05
	100	16.50±0.86**	54.2	1.70±0.06
B4	50	18.75±0.75**	48.0	2.02±0.04
	100	14.25±0.94**	60.5	2.08±0.02
B5	50	20.00±1.08**	44.5	1.90±0.12
	100	16.50±1.04**	54.2	1.80±0.14
B6	50	25.25±1.75**	29.9	2.10±0.08
	100	24.00±0.70**	33.4	2.14±0.06
B7	50	17.75±2.68**	50.7	2.14±0.06
	100	13.75±0.85**	61.9	1.98±0.02
B8	50	18.50±1.19**	48.7	1.80±0.12
	100	15.00±1.47**	58.4	2.06±0.18
B9	50	18.00±0.91**	50.0	1.52±0.06
	100	15.50±1.19**	57.0	1.40±0.02
B10	50	18.50±1.19**	48.7	1.62±0.06
	100	14.00±0.70**	61.2	1.52±0.04
B11	50	17.75±1.03**	50.7	1.42±0.02
	100	15.00±0.70**	58.4	1.38±0.04

N=6, Values are Mean±SEM

^**P<0.01 (significant), values are compared with control group