. 2008 Mar-Apr;70(2):159–164. doi: 10.4103/0250-474X.41448

TABLE 6.

EFFECT OF THIAZOLIDINONE DERIVATIVES ON YEAST-INDUCED PYREXIA

Compound code	Dose (mg/kg)	Yeast induced Pyrexia (Temp. in °C)

		0 h	1/2 h	1st h	3rd h
Control	50	37.66±0.26	37.48±0.22	37.24±0.15	36.66±0.18
Nimesulide	50	37.46±0.12	36.94±0.06^*	36.66±0.07^*	35.44±0.11^**
B₁	50	36.96±0.08	36.68±0.09^**	36.42±0.08^**	36.02±0.04^**
	100	37.00±0.13	36.72±0.06^**	36.32±0.05^**	35.60±0.04^**
B₂	50	37.10±0.12	36.80±0.13^*	36.60±0.10^**	36.44±0.06
	100	37.08±0.10	36.72±0.08^**	36.48±0.08^**	35.46±0.14^**
B₃	50	37.26±0.16	36.90±0.14^*	36.60±0.20^**	36.32±0.12
	100	36.96±0.08	36.66±0.06^**	36.22±0.06^**	35.64±0.05^**
B₄	50	37.18±0.15	36.98±0.16	36.64±0.07^*	36.28±0.04
	100	37.32±0.16	36.98±0.11^*	36.62±0.05^**	35.88±0.09^**
B₅	50	37.06±0.16	36.78±0.11^*	36.64±0.15^*	36.34±0.06
	100	37.24±0.15	36.88±0.13^**	36.64±0.12^**	35.74±0.09^**
B₆	50	37.48±0.24	36.96±0.21	36.56±0.18^**	36.22±0.10^*
	100	37.18±0.11	36.72±0.15^**	36.40±0.13^**	35.60±0.11^**
B₇	50	37.22±0.18	36.76±0.08^**	36.48±0.03^**	36.18±0.06^**
	100	37.02±0.08	36.46±0.09	36.38±0.06^**	35.56±0.08^**
B₈	50	37.18±0.18	36.80±0.10^*	36.42±0.11^**	36.20±0.06^*
	100	37.14±0.12	36.72±0.05^**	36.30±0.10^**	35.56±0.12^**
B₉	50	37.14±0.12	36.82±0.09^**	36.52±0.12^**	36.10±0.08^**
	100	37.24±0.11	36.86±0.08^*	36.46±0.13^**	35.78±0.18^**
B₁₀	50	37.64±0.08	37.04±0.06	36.54±0.06^**	36.10±0.06^*
	100	36.94±0.06	36.62±0.11^**	36.26±0.10^**	35.44±0.07^**
B₁₁	50	37.32±0.12	36.82±0.07^**	36.58±0.03^**	35.98±0.11^*
	100	37.10±0.10	36.62±0.15^**	36.20±0.07^**	35.58±0.09^**

N=6, Values are Mean±SEM

^**

P<0.01(significant)

P<0.05(significant) values are compared with control group