TABLE 2.
STABILITY STUDY DATA OF THE TABLET FORMULATIONS
| Formulation | Hardness | Friability | Thickness | Disintegration | Drug content | Increase |
|---|---|---|---|---|---|---|
| (Kg/cm2) | (%) | (mm) | time (sec) | (%) | in weight | |
| (±SD), n=6 | (±SD), n=10 | (±SD), n=10 | (±SD), n=6 | (±SD), n=4 | (%) | |
| CC IV before stability study | 4.5(0.42) | 0.354(0.01) | 4.38(0.05) | 22(1.41) | 99.23(2.64) | 0 |
| SSG IV before stability study | 3.5(0.56) | 0.476(0.04) | 4.43(0.0) | 68(4.65) | 98.84(3.24) | 0 |
| CP IV before stability study | 3.5(0.63) | 0.29(0.07) | 4.48(0.05) | 18(2.75) | 98.57(1.36) | 0 |
| CC IV 30°/ | ||||||
| 65 % RH | 4(0.41) | 0.486(0.13) | 4.6(0.05) | 16(4.42) | 97.3(2.83) | 1.406 |
| SSG IV 30°/ 65 % RH | 3(0.74) | 0.583(0.07) | 4.6(0.05) | 52(2.38) | 98.76(3.24) | 1.489 |
| CP IV 30°/ | ||||||
| 65 % RH | NA | NA | 5.5(0.17) | NA | NA | 2.836 |
| CC IV 40°/ 75% RH | 3.5(0.56) | 0.564(0.22) | 4.6(0.05) | 14(4.34) | 99.23(2.68) | 1.617 |
| SSG IV 40°/ 75% RH | 3(0.68) | 0.683(0.14) | 4.9(0.17) | 38(3.65) | 98.84(4.32) | 1.730 |
| CP IV 40°/ 75% RH | NA | NA | 6.2(0.17) | NA | NA | 3.092 |
NA - not applicable