TABLE 5.
DRUG RELEASE KINETICS PARAMETERS OF RELEASE STUDIES THROUGH DIALYSIS MEMBRANE
| Formulation Code | Cumulative% of drug release | First order Equation | Higuchi’s Equation | Korsmeyer’s-Peppas Equation | |
|---|---|---|---|---|---|
| R2 | K | R2 | n | ||
| D1 | 99.06±0.02 | 0.717 | 1.915×10-1 | 0.5742 | 0.8432 |
| D2 | 101.95±0.44 | 0.9961 | 1.952×10-1 | 0.8486 | 0.655 |
| D3 | 45.55±1.03 | 0.9184 | 2.326×10-2 | 0.9554 | 0.6292 |
| D4 | 75.96±0.31 | 0.6757 | 5.527×10-2 | 0.7666 | 0.7158 |
| D5 | 61.33±1.85 | 0.9575 | 3.661×10-2 | 0.9684 | 0.6226 |
| D6 | 105.88±0.47 | 0.9846 | 2.643×10-1 | 0.8422 | 0.6403 |
| D7 | 89.21±0.78 | 0.9258 | 8.797×10-2 | 0.8679 | 0.5776 |
| D8 | 98.98±3.01 | 0.9987 | 1.966×10-1 | 0.8578 | 0.7462 |
| C1 | 96.99±4.64 | 0.9767 | 1.473×10-1 | 0.8223 | 0.8995 |
| C2 | 74.34±1.85 | 0.7839 | 5.734×10-2 | 0.8238 | 0.8293 |
| C3 | 40.79±3.01 | 0.8825 | 1.980×10-2 | 0.9434 | 0.6747 |
| C4 | 97.60±0.78 | 0.9659 | 1.648×10-1 | 0.9692 | 0.8641 |
| C5 | 41.18±0.47 | 0.8758 | 2.233×10-2 | 0.9322 | 1.1804 |
| C6 | 62.72±1.85 | 0.9742 | 4.306×10-2 | 0.9121 | 0.9764 |
| C7 | 85.14±0.31 | 0.9939 | 8.175×10-2 | 0.9765 | 0.7609 |
| C8 | 34.20±0.35 | 0.9925 | 1.658×10-2 | 0.9303 | 0.6454 |