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COMPOSITION OF MOUTH DISSOLVING TABLETS OF CLOZAPINE
| Ingredients | F1 (mg) | F2 (mg) | F3 (mg) | F4 (mg) |
|---|---|---|---|---|
| Clozapine | 50 | 50 | 50 | 50 |
| Avicel PH-102 | 100 | 100 | -- | -- |
| Mannitol | 101 | 101 | 179 | 179 |
| Kollidon-CL | 38 | -- | -- | -- |
| Explotab | -- | 38 | -- | -- |
| Sodium saccharine | 5 | 5 | 5 | 5 |
| Camphor | -- | -- | 60 | -- |
| Ammonium bicarbonate | -- | -- | -- | 60 |
| Magnesium stearate | 3 | 3 | 3 | 3 |
| Talc | 3 | 3 | 3 | 3 |
Formulation F1 and F2 uses direct compression method and formulation F3 and F4 uses sublimation method.
