TABLE 2.
EFFECT OF THE ETHANOL EXTRACT OF CURCULIGO ORCHIOIDES (CO) ON HISTAMINE-INDUCED BRONCHOCONSTRICTION
| Groups | Dose in mg/kg p.o. | PCT (Before) T1 | PCT (After) T2 | Mean exposition time | % Protection |
|---|---|---|---|---|---|
| 1 | Control | 1.488±0.104 | 1.504±0.187 | 0.076± 0.138 | 1.06 |
| 2 | 75 CO | 1.144±0.0314 | 2.67±0.237 | 1.526±0.2075* | 57.154 |
| 3 | 150 CO | 1.278±0.1044 | 3.436±0.187 | 2.158±0.138* | 62.81 |
| 4 | 200 CO | 1.258±0.0753 | 12.716±0.934 | 11.458±0.884* | 90.11 |
| 5 | 300 CO | 1.356±0.0532 | 5.58±0.240 | 4.232±0.264* | 75.734 |
| 6 | 600 CO | 1.432±.0519 | 4.208±0.306 | 2.776±0.3166* | 65.969 |
| 7 | 1200 CO | 1.29±0.152 | 1.382±0.088 | 0.272±0.0985 | 6.66 |
| 8 | CPM (2 mg/kg) | 1.308±0.1007 | 14.81±0.19 | 13.614±0.1607* | 91.92 |
All values are expressed as mean±SEM of a sample size of n=6; level of significance chosen was *p<0.05. All treated groups were compared with control group. CPM is chlorpheniramine maleate (2 mg/kg)