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. Author manuscript; available in PMC: 2009 Dec 13.
Published in final edited form as: Annu Rev Cell Dev Biol. 2001;17:463–516. doi: 10.1146/annurev.cellbio.17.1.463

Figure 2.

Figure 2

Regulation of the MMPs. MMP regulatory mechanisms include inductive and suppressive signaling (1), intracellular signal transduction (2), transcriptional activation and repression (3), post-transcriptional mRNA processing (4), mRNA degradation (5), intracellular activation of furin-susceptible MMPs (6), constitutive secretion (7), regulated secretion (8), cell surface expression (9), proteolytic activation (10), proteolytic processing and inactivation (11), protein inhibition (12), ECM localization (13), cell surface localization (14), and endocytosis and intracellular degradation (15).