TABLE 2.

Common matrix metalloproteinase substrates^a

MMP	1	2	3	7	8	9	10	11	12	13	14	16	18	19	26
ECM Proteins:
Aggrecan	+	+	+	+	+	+	+		+	+	+
Collagen I	+	+	−	+	+	−			+	+	+		+	+	−
Collagen II	+				+	−				+	+				−
Collagen III	+	+	+	−	+	−	+			+	+	+
Collagen IV	−	+	+	+	−	+	+	−	+	−				+	+
Collagen V	−	+	+	−	−	+	+			−
Collagen VI	−	−	−			−				+
Collagen VII	+	+	+
Collagen VIII	+
Collagen IX	−	−	+							+
Collagen X	+	+	+	−						+
Collagen XI	+	+	+			+				−
Collagen XIV	−		−	−		+				+
Decorin	−	+	+	+		+
Elastin	−	+	+	+		+	+		+						−
Entactin/Nidogen	+	+	+	+					+		+
Fibrillin		+	+			+			+	+	+
Fibronectin	+	+	+	+	−	−	+		+	+	+	+		+	+
Fibulins		+		+
Gelatin I	+	+	+	+		+	+		+	+	+			+	+
IGFBPs	+	+	+					+
Laminin	+	+	+	+		+		−	+		+				−
Link Protein	+	+	+	+		+	+
Myelin Basic	+	+	+	+		+			+
Osteonectin		+	+	+		+				+
Tenascin	+	+	+	+		−								+
Vitronectin	+	+	+	+		+			+		+
Other Proteins:
α1-AC	+	+	+			−
α2-M	+	−	+		+	+		+	+	+	+
α1-PI	+	+	+	+	+	+		+	+		+				+
Casein	+	−	+	+		+	+	−		+				+	−
C1q	+	+	+		+	+				+
E-cadherin			+	+
Factor XII					−				+	+	+
Fibrin	+	+	+			+					+
Fibrinogen	+	+	+	+	+	+	+		+	+	+				+
IL1α	−	−	−			−
IL1β	+	+	+			+
ProMMP2											+	+
ProTGFβ		+				+
ProTNFα	+	+	+	+		+			+		+
Plasminogen		+	+	+		+			+						−
Substance P		+	+		+	+
T kininogen		−	+			−

^aThe symbols indicate whether the indicated protein is (+) or is not (−) digested by the indicated MMP.

Abbreviations: α1-AC, α1-antichymotrypsin; α2-M, α2-macroglobulin; α1-PI, α1-proteinase inhibitor. Adapted from Woessner & Nagase 2000 with additional data from Ashworth et al. 1999, Hiller et al. 2000, Hiraoka et al. 1998, Manes et al. 1997, Noe et al. 2001, Park et al. 2000, Stracke et al. 2000, Sternlicht et al. 2001, and Uria & Lopez-Otin 2000.