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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Gut. 2009 Jul 21;58(11):1538–1544. doi: 10.1136/gut.2008.171280

Table 3.

Liver biopsy features (n = 29)

Histological findings Number (%)
Steatosis score
 0; Minimal (<5%) 0
 1; Mild (>5-33%) 5 (17.2)
 2; Moderate (>33% and 66%) 11 (37.9)
 3; Severe (>66%) 13 (44.8)
Lobular Inflammation score
 0; No foci 1 (3.4)
 1; Mild 26 (89.7)
 2; Moderate 1 (3.4)
 3; Severe 1 (3.4)
Hepatocellular ballooning
 0; None 24 (82.8)
 1; Few 5 (17.2)
 2; Prominent 0
NAFLD activity score
 1-2 5 (17.2)
 3-4 20 (70)
 5 or more 4 (13.8)
Fibrosis
 Stage 0 12 (41.3)
 Stage 1 Perisinusoidal or periportal
  1A Delicate perisinusoidal 3 (10.3)
  1B Dense perisinusoidal 1 (3.5)
  1C Periportal only 2 (6.9)
 Stage 2 Perisinusoidal and periportal 5 (17.2)
 Stage 3 Bridging fibrosis 4 (13.8)
Stage 4 Cirrhosis 2 (6.9)
Mallory's Hyaline 4 (13.8)

Liver biopsy features were graded and staged according to the scoring system proposed by Kleiner et al.31 The grade of steatosis (0-3), lobular inflammation (0-3), and ballooning (0-2) were then combined to determine the NAFLD activity score (0-8) as proposed.31