Fig. 4.

Effect of HE2000 on cellular infiltrates in the mouse model of lipopolysaccharide (LPS)-induced lung injury. Male C57 black/six mice (n = 3–6 per group) were pretreated (24 h before LPS challenge) with HE2000 (oral gavage; n = 6), dexamethasone (Dex) (5 mg/kg; n = 3) or vehicle and with a second dose of HE2000, Dex or vehicle 60 min after intratracheal administration of 100 µg of LPS. Two days later, bronchoalveolar lavage fluid (BAL) was obtained. Cellular infiltrates were enumerated under light microscopy using a cell counter. Data are expressed as numbers of cells per ml of BAL ± standard deviation.