Fig. 6.

Effect of HE2000 on bacterial burden in lungs of cystic fibrosis transmembrane conductance regulator mice. Mice (nine per group) were inoculated with a 1 : 35 dilution of Pseudomonas aeruginosa-laden agarose beads. HE2000 (12 or 120 mg/kg) or vehicle was delivered subcutaneously (0·1 ml) to mice 24 h before and 1 h after challenge with bacteria-laden beads. Bacterial colony counts were performed on whole lung homogenates taken 24 h after the final challenge. Data are expressed as natural log of colony-forming units per lung.