Table 1.
Effect of subcutaneous HE2000 treatment on an influenza A (H1N1) virus infection in mice.
| Tox controls |
Infected, treated mice |
|||||
|---|---|---|---|---|---|---|
| Compound | Dose (mg/kg/day) | Surv/total | Mean host weight change† (g) | Surv/total | Mean day to death‡ ± s.d. | Mean day 11 SaO2 (% ± s.d.) |
| HE2000 | 100 | 3/3 | 1·7 | 0/10 | 8·8 ± 0·6 | 75·0 ± 0·0 |
| 10 | 3/3 | 0·6 | 0/10 | 8·4 ± 0·7 | 75·0 ± 0·0 | |
| 1 | 3/3 | 1·1 | 0/10 | 9·1 ± 0·3* | 75·0 ± 0·0 | |
| Ribavirin | 75 | 3/3 | 0·2 | 10/10*** | > 21·0 ± 0·0*** | 88·4 ± 2·5*** |
| Vehicle | – | – | – | 0/20 | 8·7 ± 0·5 | 75·0 ± 0·0 |
| Normal controls | – | 3/3 | 1·5 | – | – | 89·0 ± 1·0 |
*
P < 0·05;
***
P < 0·001 compared to saline-treated controls.
†
Difference between initial weight and weight 18 h after final treatment.
‡
Mean day to death of mice dying prior to day 21; s.d.: standard deviation.