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. Author manuscript; available in PMC: 2010 Sep 26.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 26;89(5):354–363. doi: 10.1016/j.tube.2009.07.006

Table 1.

Cpd. PubChem1
SID		 R1 R2 R3 X IC902
(μM)		 SI3
1a 861394 cyclopropyl Me H C-methoxy <0.19 >204
1b 855596 cyclopropyl H ethyl CH <0.39 >102
1c 24837296 cyclopropyl H acetyl CH 1.6 >26
1d 855614 ethyl H H CH 3.1 >13
2a 26660376 1-heptyl 2-pyrazinyl --- --- <0.19 >12
2b 26660314 1-hexyl 4-
methylcarboxyethylthiazol-
2-yl		 --- --- <0.19 >23
2c 24784170 3-methyl-1-
butyl		 4-
methylcarboxyethylthiazol-
2-yl		 --- --- 0.22 38
2d 852129 ethyl benzimidazol-2-yl --- --- 0.42 >95
2e 24807142 1-butyl 5-iso-propyl-1,3,4-
thiadiazol-2-yl		 --- --- 0.84 >48
1

PubChem Substance Identifier; see http://pubchem.ncbi.nlm.nih.gov

2

Antituberculosis activity, defined as the concentration of drug inhibiting 90% growth relative to untreated controls as measured fluorometrically

3

Selectivity index, defined as CC50/IC90