Table 2.
Receptor selectivity of chemokines (continued from Table 1)
| Chemokines (systematic name) | Receptor(s) activated |
|---|---|
| C-γ | |
| Lymphotactin (XCL1) | XCR1 |
| CXC-α | |
| GRO-α (CXCL1) | CXCR2 |
| GRO-β (CXCL2) | CXCR2 |
| GRO-γ (CXCL3) | CXCR2 |
| PF4 (CXCL4) | CXCR3B |
| ENA78 (CXCL5) | CXCR2 |
| GCP2 (CXCL6) | CXCR1, CXCR2 |
| NAP2 (CXCL7) | CXCR2 |
| IL8 (CXCL8) | CXCR1, CXCR2 |
| Mig (CXCL9) | CXCR3 |
| IP10 (CXCL10) | CXCR3 |
| ITAC (CXCL11) | CXCR3 |
| SDF1 (CXCL12) | CXCR4 |
| BLC (CXCL13) | CXCR5 |
| BRAK (CXCL14) | Unknown |
| Lungkine (CXCL15) | Unknown |
| SRPSOX (CXCL16) | CXCR6 |
| CXXXC-δ | |
| Fractalkine (CX3CL1) | CX3CR1 |
Classification system of the various chemokines, including the receptors that they activate. Chemokines are classified based on their structure, with most falling into the CXC- and CC-chemokine classes. Most chemokines have a common name and a systematic name. Chemokines activate a family of receptors known as the G-protein-coupled receptors, and most are able to activate more than one. BLC, B lymphocyte chemoattractant; BRAK, breast- and kidney-expressed chemokine; CCLx, CC ligand; CCRx, CC receptor; ELC, Epstein–Barr virus-induced molecule 1 ligand chemokine; ENA, epithelial neutrophil-activating protein; GCP, granulocyte chemotactic protein; GRO, growth-related oncogene; HCC, haemofiltrate CC chemokine; IL, interleukin; IP, interferon-γ-inducible protein; ITAC, interferon-γ-inducible T cell α chemoattractant; LARC, liver and activation-regulated chemokine; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; Mig, monokine induced by interferon-γ; MIP, macrophage inflammatory protein; MPIF, myeloid progenitor inhibitory factor; NAP, neutrophil-activating peptide; PARC, pulmonary and activation-regulated chemokine; PF4, platelet factor 4; RANTES, regulated upon activation, normal T-cell expressed and secreted; SDF, stromal cell-derived factor; SLC, secondary lymphoid tissue chemokine; SRPSOX, scavenger receptor that binds phosphatidylserine and oxidized lipoprotein; TARC, thymus and activation-regulated chemokine; TECK, thymus-expressed chemokine.