TABLE I.
Characteristics of study participants
| CD4 Count | % CD8+IFN-γ+ Cells (ICS)b | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Time | Viral | at Time | ||||||||
| Postinfection at | Set Point | of Analysis | ||||||||
| Patient ID | Analysis (wk) | (copies/ml)a | (cells/mm3) | HLA-A | HLA-B | HLA-C | Nef | Gag | Pol | Env |
| CAP045 | 41 | 472 | 904 | 2301/2902 | 1510/4501 | 602/1602 | 0.19 | |||
| CAP228 | 37 | 974 | 1,411 | 2301/2601 | 4403/5101 | 3c/7 | 0.97 | 0.39 | 0.16 | 0.07 |
| CAP084 | 19 | 4,565 | 623 | 2902/7401 | 1503/4407 | 2c/7 | 2.87 | 0.27 | ||
| CAP257 | 30 | 9,859 | 489 | 2301/2902 | 4202/4403 | 1701/— | 0.55 | |||
| CAP271 | 22 | 12,732 | 628 | 205/2301 | 1401/4403 | 303/804 | 0.04 | 0.06 | ||
| CAP217 | 31 | 24,836 | 529 | 202/2901 | 1503/5801 | 210/602 | 1.15 | |||
| CAP040 | 26 | 26,325 | 417 | 30c/— | 1510/4201 | 304/1701 | 0.3 | |||
| CAP229 | 38 | 37,686 | 690 | 101/— | 5801/— | 602/— | 0.67 | |||
| CAP088 | 26 | 46,304 | 864 | 29c/66 | 4501/5802 | 602/— | 1.26 | 0.5 | 3.5 | 3.65 |
| CAP030 | 42 | 63,338 | 537 | 2c/34 | 4403/4501 | 4c/16 | 0.88 | |||
| CAP129 | 32 | 84,959 | 676 | 26c/8001 | 18c/8101 | 202/4c | 0.09 | 0.08 | 0.54 | |
| CAP174 | 24 | 117,279 | 404 | 301/7401 | 4901/5802 | 6c/7 | 0.24 | |||
| CAP239 | 32 | 160,922 | 1,092 | 101/2902 | 4201/5801 | 602/7101 | 0.41 | 1.55 | ||
| CAP256 | 23 | 199,234 | 456 | 2902/6601 | 1503/5802 | 4c/602 | 1.29 | 0.7 | 0.4 | |
| CAP206 | 36 | 257,196 | 329 | 3204/74c | 702/4403 | 210/702 | 0.13 | |||
| CAP210 | 31 | 289,662 | 398 | 6802/— | 1510/— | 304/— | 9.44 | |||
| Median (n = 16) (47)d | 31 (24) | 41,995 (36,400) | 580 (464) | 0.69 | 0.55 | 0.54 | 0.335 | |||
| Range (n = 16) | 19–42 | 471–289,662 | 329–1,411 | |||||||
a
Measured by taking the mean of three time points around 52 ± 6 wk.
b
Peptide pools found to stimulate a positive IFN-γ response by intracellular cytokine staining (ICS).
c
Low-resolution HLA typing only.
d
Median time postinfection at recruitment, viral set point, and CD4 count did not differ significantly between the subgroup studied in detail (n = 16) and the larger group (n = 47).