Figure 1.

GHR polypyrimidine tract. (A) Schematic representation of the typical eukaryotic intronic nucleotide sequence upstream the intron/exon splice junction (top) and the nucleotide composition of the intronic region upstream GHR exon 8 (bottom). Pyrimidines are shown in uppercase letters; position and length of the polypyrimidine tract (Poly-Y) are also indicated. (B) IVS7-6T>A. Chromatograms showing partial DNA sequences for the patient, his parents and a normal control are presented. The position of the mutation is indicated by the arrows. Y, pyrimidines; n, any nucleotide.