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JNK signaling transactivates p53. (A) Luciferase reporter under control of p53-dependent mdm2 promoter was introduced into 10.1 cells with various constructs as indicated. Luciferase activity is normalized per β-galactosidase values. Each column represents an average value of three experiments (each in duplicate). (B) Transactivation of endogenous p53 in MCF7 cells stimulated by ΔMEKK1 is assessed as described in A.
