Figure 5. Differential sensitivity of α-actinin-depleted cells to contractile inhibitors.

Mean speeds of control, α-actinin-1-depleted, and α-actinin-4-depleted cells for 6 hr following 1 hr of incubation with 10 µM ML7 or 10 µM Y27632. Compared to motility of ML7 treated control cells, knockdown of either isoform significantly reduces cell motility (**p<0.001). Depletion of α-actinin-4 (*p<0.05), but not of α-actinin-1, reduces the motility of Y27632 treated cells to levels observed in untreated cells.