Table 4.
Toxicity
| Parameter | Treatments 1, 2, and 2.5(n = 78) |
Treatment 3(n = 69) |
Treatment 4(n = 67) |
|||
|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | |
| No. of days for ANC < 500/μL | ||||||
| Median | 5 | 10 | 9 | |||
| Range | 0-16 | 0-16 | 0-39 | |||
| No. of days for platelets < 20,000/μL | ||||||
| Median | 0 | 7 | 6 | |||
| Range | 0-52 | 0-20 | 0-170 | |||
| No. of platelet transfusions | ||||||
| Median | 0 | 7 | 3 | |||
| Range | 0-21 | 0-37 | 0-36 | |||
| No. of RBC units transfused | ||||||
| Median | 0 | 4 | 2 | |||
| Range | 0-23 | 0-11 | 0-22 | |||
| Days of hospitalization | ||||||
| Median | 9 | 13 | 20 | |||
| Range | 0-39 | 3-31 | 0-67 | |||
| No. of days of TPN | ||||||
| Median | 0 | 0 | 0 | |||
| Range | 0-0 | 0-6 | 0-15 | |||
| No. of days of IV narcotics | ||||||
| Median | 0 | 0 | 0 | |||
| Range | 0-6 | 0-11 | 0-61 | |||
| Maximum total bilirubin, mg/dL | ||||||
| Median | 0.8 | 0.9 | 0.9 | |||
| Range | 0.2-2.8 | 0.2-4.7 | 0.3-5.8 | |||
| Maximum alkaline phosphatase, IU/L | ||||||
| Median | 113 | 106 | 109 | |||
| Range | 40-371 | 10-552 | 50-351 | |||
| Maximum creatinine, mg/dL | ||||||
| Median | 1.1 | 1.1 | 1.1 | |||
| Range | 0.7-5.5 | 0.7-2.9 | 0.7-3.2 | |||
| Needed platelet transfusion | 13 | 17 | 67 | 97 | 61 | 91 |
| Needed RBC transfusion | 25 | 32 | 69 | 93 | 54 | 82 |
| Needed hospitalization | 76 | 99 | 69 | 100 | 65 | 97 |
| Needed TPN | 0 | 0 | 3 | 4 | 9 | 13 |
| Needed IV narcotics | 14 | 18 | 24 | 35 | 30 | 45 |
| ≥ Grade 3 (NCI common toxicity criteria) | ||||||
| GI | 10 | 13 | 15 | 22 | 17 | 25 |
| Hepatic | 0 | 0 | 5 | 7 | 3 | 4 |
| Pulmonary | 2 | 3 | 2 | 3 | 1 | 1 |
| Cardiac | 4 | 5 | 3 | 4 | 4 | 6 |
| Cutaneous | 1 | 1 | 6 | 9 | 0 | 0 |
| Infection | 9 | 12 | 21 | 30 | 19 | 28 |
| Febrile neutropenia | 12 | 15 | 28 | 41 | 24 | 36 |
| CNS | 0 | 0 | 3 | 4 | 0 | 0 |
| Peripheral nervous system | 0 | 0 | 0 | 0 | 0 | 0 |
| Metabolic (Cr) | 2 | 2.5 | 0 | 0 | 0 | 0 |
Abbreviations: ANC, absolute neutrophil count; RBC, red blood cells; TPN, total parenteral nutrition; IV, intravenous; IU/L, international units per liter; NCI, National Cancer Institute; Cr, serum creatinine.