Table 3.
Toxicity
| Toxicity | % of Patients by Toxicity Grade |
|
|---|---|---|
| Grade 3 | Grade 4 | |
| Hematologic | ||
| Anemia | 3.1 | 1.6 |
| Leukocytes | 20.3 | 9.4 |
| Lymphopenia | 0 | 1.6 |
| Neutropenia | 12.5 | 45.3 |
| Thrombocytopenia | 9.4 | 4.7 |
| Febrile neutropenia | 4.7 | 3.1 |
| Nonhematologic | ||
| Sinus bradycardia | 1.6 | 0 |
| Hypotension | 0 | 1.6 |
| LV diastolic dysfunction | 1.6 | 0 |
| Fatigue/weakness | 14.1 | 0 |
| Anorexia | 1.6 | 0 |
| Dehydration | 4.7 | 0 |
| Diarrhea | 6.3 | 0 |
| Mucositis | 1.6 | 0 |
| Nausea/vomiting | 6.3 | 0 |
| Infection | 1.6 | 0 |
| Hypocalcemia | 1.6 | 1.6 |
| Hyponatremia | 9.4 | 1.6 |
| Hypokalemia | 1.6 | 0 |
| Ataxia/walking | 3.1 | 0 |
| Dizziness | 1.6 | 0 |
| Dyspnea | 0 | 1.6 |
| Musculoskeletal | 7.8 | 0 |
| Bevacizumab associated | ||
| Hypertension | 7.8 | 0 |
| Cardiac ischemia | 0 | 1.6 |
| Pulmonary hemorrhage | 1.6 | 0 |
| Abdominal hemorrhage | 1.6 | 0 |
| Epistaxis | 9.4 | 0 |
| Thrombosis/embolism | 0 | 1.6 |
NOTE. Total number of patients = 64. Two grade 5 toxicities occurred: one patient experienced multiorgan failure, and one patient experienced lung infection and grade 3 to 4 neutropenia.
Abbreviation: LV, left ventricle.