Table 4.
Correlative Markers With HR Comparing Baseline High to Low Levels
| Marker | Marker Level |
Statistical Analysis |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline |
Week 7 |
PFS |
OS |
||||||
| Median | Range | Median | Range | % Change From Baseline | HR | P | HR | P | |
| VEGF, pg/mL | 52 | −6.4-161.0 | 610 | 261-844 | 525.7 | 0.95 | .9 | 1.65 | .19 |
| VCAM, ng/mL | 626 | 313-1,559 | 740 | 567-2,076 | 152 | 2.11 | .05 | 2.69 | .01 |
| E-selectin, ng/mL | 32 | 11-107 | 21 | 15-68 | −6.6 | 0.91 | .79 | 0.88 | .75 |
| bFGF, pg/mL | 5.01 | 1.65-27.5 | 13.7 | 4.2-127 | 4.63 | 1.48 | .28 | 2.06 | .06 |
| ICAM, ng/mL | 291 | 143-471 | 279 | 149-552 | −28 | 0.75 | .44 | 0.48 | .06 |
Abbreviations: HR, hazard ratio; PFS, progression-free survival; OS, overall survival; VEGF, vascular endothelial growth factor; VCAM, vascular cell adhesion molecule; bFGF, basic fibroblast growth factor; ICAM, intercellular cell adhesion molecule.