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IFNγ activates JAK-STAT signaling pathway in hfRPE cells. A: IFNγ stimulated tyrosine phosphorylation of STAT1 in hfRPE cells (15 min) and can be blocked by anti-IFNGR1 blocking antibody. GAPDH was used as loading control. B: regulation of interferon regulatory factor (IRF) gene expression in hfRPE cells. Cells were treated with serum-free medium [SFM (Ctrl)], IFNγ, or cycloheximide (CHX) + IFNγ for 4 h. ICSBP, IFN consensus sequence-binding protein.
