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. Author manuscript; available in PMC: 2009 Dec 14.
Published in final edited form as: J Proteome Res. 2008 Jul 18;7(9):4178–4182. doi: 10.1021/pr800224v

Figure 2.

Figure 2

MALDI-TOF mass spectra of reaction products of bovine insulin with glutaraldehyde and sodium cyanoborohydride. (a) insulin alone; (b) insulin with 0.5% glutaraldehyde and 100 mM sodium cyanoborohydride in water at room temperature for 10 minutes; and (c) MS/MS of the glutaraldehyde-modified insulin β chain observed 884.5 for MH44+ ion. Both N-terminus and the lysine residue were modified and the a1 at 188.06 was observed with enhanced intensity.