Figure 4.
Simulation results of the model described in Fig. 3. Macromolecular crowding agents were assumed to increase the on-rate constants for complex formation (k1, k−2, k3,k−4, k5, and k−6) by a factor α and to decrease the off-rate constants for complex dissociation (k−1, k2, k−3, k4, k−5, and k6) by the same factor α. The other parameters were as per the legend of Fig. 3. For α= 1, crowding effects are assumed to be absent. (a) The flux J. (b) Magnification of the area near the origin in a. (c) The combined flux–response coefficient, for α = 1, 2, and 3.