TABLE 3.
Association of uracil misincorporation (UrMis; in pg/μg DNA) and risk of adenoma recurrence1
| Adenoma | No adenoma | OR (95% CI)2 | OR (95% CI)3 | |
| UrMis in mucosa4 | 1.46 (0.94, 2.28) | 1.43 (0.91, 2.25) | ||
| n | 36 | 56 | ||
| Mean ± SD | 4.45 ± 0.79 | 4.12 ± 0.92 | ||
| Median (interquartile range) | 4.35 (1.08) | 4.24 (1.49) | ||
| UrMis in WBC4 | 0.64 (0.32, 1.28) | 0.66 (0.33, 1.32) | ||
| n | 30 | 30 | ||
| Mean ± SD | 2.33 ± 1.05 | 2.93 ± 2.32 | ||
| Median (interquartile range) | 2.11 (1.57) | 2.23 (2.23) |
1
Analysis included participants who received placebo or folic acid supplementation and were then evaluated for adenoma recurrence within the first 3 y. OR, odds ratio; WBC, white blood cell count. Wilcoxon's P values for adenoma recurrence status: mucosa (P = 0.18), WBC (P = 0.58).
2
OR for adenoma recurrence adjusted for age by using logistic regression.
3
OR for adenoma recurrence adjusted for age and folate randomization status by using logistic regression.
4
UrMis as a continuous variable (calculated per SD of UrMis).