Fig. 7.

Postischemic leukocyte behavior (over 2–10 h reperfusion), following 48 h exposure to topically applied RAGE antisense or missense ODN in nondiabetic intact [n = 4 (antisense), and n = 4 (missense)], OVX [n = 5 (antisense), and n = 4 (missense)], and OVE [n = 6 (antisense), and n = 5 (missense)] females. The data are expressed as the percentage of the viewed venular area occupied by adherent leukocytes present within the intravascular compartment [missense (white bars) or antisense (black bars)] or as the area percentage of leukocytes found extravascularly (gray-shaded portion of bars). Total leukocyte presence (intravascular + extravascular leukocytes) is represented by the combined height of the gray/white or gray/black bars. For definition of symbols, see Fig. 5 legend. It should be noted that in all female groups, no significant differences in leukocyte behavior were observed when comparing antisense to missense ODN treatments at each time point. This is strongly suggestive of an absence of postischemic RAGE influence in nondiabetic rats, irrespective of hormone status.