Table 3.
Hemodynamic effects of simultaneous variation of left ventricular pacing site and interventricular pacing delay with biventricular pacing during acute right ventricular pressure overload
| Best Settings |
|||||
|---|---|---|---|---|---|
| Functional Index | LVPS | VVD†, ms | Change From Worst Settings | Change From Default Settings‡ | LVPS-VVD Interaction |
| CO, l/min | No effect | 0 | 5±2% | 2±2% | P = 0.980 |
| Interventricular synchrony (APP)* | IM | +20 | 0.32±0.03 | 0.04±0.02 | P = 0.047 |
| LV dP/dtmax, mmHg/s | No effect | No effect | P = 0.199 | ||
| RV dP/dtmax, mmHg/s | No effect | +40 | 20±5% | 6±2% | P = 0.814 |
Values are mean ± SE. IM, inferomedial.
*
Positive APP indicates RV preceding LV pressure.
†
Positive VVD indicates RV-first pacing.
‡
Default settings (the most common clinically implemented biventricular pacing protocol): LVPS = circumflex; VVD = 0 ms.