Table 1.
Multiple ligands and functions of CI-M6PR
| Sites and ligands | CI-M6PR functions | Associated Diseases | Ref. |
|---|---|---|---|
| M6P binding sites (repeats 1–3 and 9) | [38] | ||
| ~ 50 lysosomal enzymes (secreted cathepsins) | Lysosome biogenesis | Most of lysosomal diseases | [71] |
| Tumor dissemination | Cancer metastasis | [118] | |
| Latent TGFβ complex | TGFβ activation | Wound healing | [100] |
| Granzyme B | Cell entry and apoptosis | Immune cytotoxic cell response | [111] |
| Leukemia Inhibitory Factor, Macrophage-Colony-Stimulating Factor | Cell entry and degradation in lysosome | Haematopoietic disorders, multiple myeloma, Castelman disease, polycythemia vera | [76] |
| Proliferin | Cell growth, angiogenesis | Fibrosarcomas | [114] |
| gD, glycoprotein of herpes virus | Virus entry | Viral infection | [110] |
| Renin | Cardiac (pro)renin uptake | Cardiovascular disorders | [84] |
| IGFII binding site (repeat 11) | Cell entry and degradation in lysosome | Cell growth in embryogenesis and oncogenesis | [36] |
| uPAR/plasminogen binding site (repeat 1) | Regulation cell surface uPAR, activation uPA, activation of TGFβ | Fibrinolysis, cell adhesion and migration | [104] |
| Retinoic acid (unknown site) | Modulation of retinoic acid action | Cell growth in embryogenesis and oncogenesis | [44] |