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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Gene Med. 2009 Nov;11(11):1005–1011. doi: 10.1002/jgm.1385

Figure 3.

Figure 3

Ex vivo analysis of primary patient samples. (A) Toxicity and (B) replication of viral vectors AdWT, Ad 5/3 and CRAd-Survivin-5/3 in primary GBM samples. Infection was carried out as described earlier and tissue slices were analysed for LDH release to measure toxicity or with qPCR for replication. A representative example is shown. (C) Toxicity and (D) replication of viral vectors in matched normal brain tissues. Asterisks (*, **) indicate a statistically significant difference (p < 0.05) at specified time points in toxicity/gene levels relative to AdWT and Ad 5/3, respectively