Figure 2.

Molecular dynamics simulation of the β-roll and β-helix insulin monomeric models with increasing temperature in acidic conditions. Backbone RMSDs of the β-roll (A) and β-helix (B) models relative to their initial structures (upper left corner) as a function of simulation time at 300 K, 345 K, and 375 K. Final structures are shown at the right in order of increasing temperature (lower to upper).