Table 3.

Baseline Fasting Glucose, Insulin, HOMA-IR, AUCs for Insulin, GLP-1, and GIP During a Meal Tolerance Test and Changes 6 Months After RYGB

	RYGB (N = 12a)
Fasting glucose (mg/dL), baseline	91.9 ± 10.3
Change in fasting glucose	−9.6 ± 14.2
p value	0.03
Fasting insulin (µU/mL), baseline	22.9 ± 14.0
Change in fasting insulin	−12.6 ± 12.3
p value	<0.01
HOMA-IR, baseline	5.1 ± 2.8
Change in HOMA-IR	−2.9 ± 2.6
p value	<0.01
AUC insulin, baseline	191 ± 62
Change in AUC Insulin	2.1 ± 103
p value	0.95
AUC GLP-1, baseline	3.7 ± 2.2
Change in GLP-1 AUC	11.6 ± 5.4
p value	<0.01
AUC GIP, baseline	207.4 ± 65.8
Change in GIP AUC	−4.5 ± 89.9
p value	0.87

HOMA-IR homeostasis model assessment, AUC area under the curve, MTT meal tolerance test

^aA total of 12 subjects underwent a third inpatient evaluation 6 months after RYGB (visit 3): nine subjects from the original RYGB group and three from the diet group who underwent RYGB after completing V1 and V2