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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Development. 2007 Jun 13;134(14):2615–2625. doi: 10.1242/dev.000877

Fig. 10. Schematic representation of bone formation in calvaria.

Fig. 10

Bone formation is a multistep process that requires first an initial condensation stage. This step enables the cells to start the differentiation process where some early markers such as Cbfa1/Runx2, Osterix are expressed. At later stages, other osteogenic markers such as AP, BSP, osteocalcin and osteonectin are produced. Lack of ICAP-1 expression slows down proliferation and in addition the ability of mesenchymal cells to compact. Since the compaction is a very early event in the osteoblast differentiation pathway, expression of more distal maker are consequently reduced in Icap-1−/− animals.