Table 2.
Intrahepatic fat content and oral-glucose-tolerance variables before and after 6 months of diet-induced weight loss or diet-induced weight loss + exercise training
| Diet (n=9) |
Diet + exercise (n=9) |
Between-group P value |
|
|---|---|---|---|
| Intrahepatic Fat (%) | |||
| Baseline | 7.1 ± 1.1 | 8.6 ± 2.2 | |
| Final | 3.4 ± 0.6 | 4.6 ± 1.6 | |
| Absolute change | −3.7 ± 1.1 | −3.8 ± 1.2 | .95 |
| Within-group P value | .01 | .02 | |
| Insulin Sensitivity Index | |||
| Baseline | 2.6 ± 0.6 | 3.5 ± 0.8 | |
| Final | 3.7 ± 0.8 | 5.3 ± 0.9 | |
| Absolute change | 1.1 ± 0.4 | 1.8 ± 1.1 | .84 |
| Within-group P value | .04 | .04 | |
| HOMA-IR | |||
| Baseline | 5.5 ± 1.3 | 4.1 ± 1 | |
| Final | 4.0 ± 1.2 | 2.9 ± 1 | |
| Absolute change | 1.5 ± 0.6 | 1.2 ± 0.4 | .41 |
| With in-group P value | .047 | .02 | |
| Glucose AUC (×103 mg · min/dL) | |||
| Baseline | 17.7 ± 1.0 | 18.0 ± 1.6 | |
| Absolute change | 15.7 ± 0.7 | 15.4 ± 1.3 | |
| Change | −2.0 ± 0.6 | −2.3 ± 1.0 | .20 |
| Within-group P value | .02 | .04 | |
| Insulin AUC (×103 μU · min/mL) | |||
| Bas eline | 13.6 ± 2.5 | 10.2 ± 1.6 | |
| Final | 10.2 ± 1.7 | 6.8 ± 1.1 | |
| Absolute change | −3.4 ± 1.6 | −3.4 ± 1.1 | .32 |
| Within-group P value | .067 | .045 | |
Values are as mean ± SE. ISI, composite insulin sensitivity index; AUC, area under the curve; HOMA-IR, Homeostasis model assessment of insulin resistance.