Table A1.
Common Chemotherapy Regimens for Metastatic Colorectal Cancer
| Regimen | Reference No. | Description | Cycle Length (weeks) |
|---|---|---|---|
| FOLFOX4 | 31 | Oxaliplatin 85 mg/m2 day 1 | 2 |
| LV 200 mg/m2 days 1-2 | |||
| FU 400 mg/m2 days 1-2 | |||
| FU 600 mg/m2 CIVI 22 hours days 1-2 | |||
| FOLFOX6 | 32 | Oxaliplatin 100 mg/m2 day 1 | 2 |
| LV 400 mg/m2 day 1 | |||
| FU 400 mg/m2 day 1 | |||
| FU 2,400-3,000 mg/m2 CIVI 46 hours days 1-2 | |||
| FLOX | 33 | Oxaliplatin 85 mg/m2 day 1 on weeks 1, 3, 5 | 8 |
| FU 500 mg/m2 bolus weekly, weeks 1-6 | |||
| LV 500 mg/m2 bolus weekly, weeks 1-6 | |||
| XELOX | 34 | Oxaliplatin 130 mg/m2 day 1 | 3 |
| Capecitabine 1 g/m2 twice a day, days 1-14 | |||
| FOLFIRI | 35 | Irinotecan 180 mg/m2 day 1 | 2 |
| LV 200 mg/m2 days 1-2 | |||
| FU 400 mg/m2 bolus days 1-2 | |||
| FU 600 mg/m2 CIVI 22 hours days 1-2 | |||
| IFL | 36 | Irinotecan 100-125 mg/m2 weekly for 4 weeks | 6 |
| LV 20 mg/m2 weekly for 4 weeks | |||
| FU 400-500 mg/m2 bolus weekly for 4 weeks | |||
| XELIRI | 37 | Irinotecan 200-250 mg/m2 day 1 | 3 |
| Capecitabine 1 g/m2 twice a day, days 1-14 |
Abbreviations: LV, leucovorin; FU, fluorouracil; FOLFOX, oxaliplatin, LV, and FU; CIVI, continuous intravenous infusion; FLOX, oxaliplatin, LV, and FU; XELOX, capecitabine and oxaliplatin; FOLFIRI, irinotecan, LV, and FU; IFL, irinotecan, LV, and FU; XELIRI, irinotecan and capecitabine.