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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2009 Aug 8;124(3):422–427. doi: 10.1016/j.jaci.2009.06.035

Figure 1.

Figure 1

Overview of the leukotriene pathway, demonstrating the key enzymes encoded by genes with variants associated with asthma, aspirin intolerant asthma, or the pharmacologic response to leukotriene modifier therapy. Highlighted boxes in red demonstrate known genetic associations. AERD = association with aspirin exacerbated respiratory disease, PG = pharmacogenetic association. (Modified from Drazen, et al, N Engl J Med, 1999)