Table 1.
Different types of matrix metalloproteinases, their location within tissues and source of activation from a pro-form.
| Enzyme | MMP | Location | Activation |
|---|---|---|---|
| Collagenases | MMP1 | Secreted | MMP3 |
| MMP8 | Secreted | MMP3 | |
| MMP13 | Secreted | MMP14/TIMP2/MMP3 | |
| MMP18* | Secreted | Unknown | |
| Gelatinases | MMP2 | Secreted | MMP14/TIMP2 |
| MMP9 | Secreted | MMP3/MMP13 | |
| Matrilysin | MMP7 | Secreted | MMP3 |
| MMP26 | Secreted | Unknown | |
| Membrane-type MMPs | MMP14 | Membrane | Furin |
| MMP15 | Membrane | Furin | |
| MMP16 | Membrane | Furin | |
| MMP17 | Membrane | Furin | |
| MMP24 | Membrane | Furin | |
| MMP25 | Membrane | Furin | |
| Metalloelastase | MMP12 | Secreted | Unknown |
| Stromelysin | MMP3 | Secreted | MMP14/TIMP2 |
| MMP10 | Secreted | Unknown | |
| MMP11 | Secreted | Furin | |
| Others | MMP19 | Secreted | Unknown |
| MMP20 | Secreted | Unknown | |
| MMP21 | Secreted | Unknown | |
| MMP23 | Secreted | Furin | |
| MMP27 | Secreted | Unknown | |
| MMP28 | Secreted | Furin | |
*
MMP18 is only found in Xenopus.
MMP: Matrix metalloproteinase; TIMP: Tissue inhibitor of matrix metalloproteinase.