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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2009;1(2):228–236. doi: 10.1002/wsbm.12

Figure 4.

Figure 4

Sox protein redundancy and the regulation of Oct-3/4:Sox target genes. Oct-3/4 is proposed to work in conjunction with Sox2, as well as Sox4, Sox11 and Sox15, in ES cells to regulate the transcription of the Oct-3/4 and Sox2 genes as well as the transcription of a large set of downstream target genes. Sox2 is also proposed to indirectly regulate the transcription of the Oct-3/4 gene by upregulating Nr5a2 and downregulating Nr2f2, which are positive and negative regulators of the Oct-3/4 gene, respectively. As indicated by the dotted lines, it remains to be determined whether Sox4, Sox11 or Sox15 influence the expression of the Oct-3/4 and Sox2 genes.