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Elevating the expression of Sox2 reduces the expression of genes required for the self-renewal of ES cells. Elevating the levels of Sox2 in EC and ES cells reduces the expression of the Oct-3/4 gene and the expression of downstream Sox:Oct target genes, such as FGF-4, Nanog and UTF1. As indicated by the dotted lines, it is unclear whether Oct-3/4 continues to positively influence the expression of Oct-3/4:Sox2 target genes when Sox2 is overexpressed.
