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Oct-3/4 and Sox2 function as molecular rheostats. Increasing or decreasing the levels of either Sox2 or Oct-3/4 in ES cells promotes their differentiation. However, the spectra of cell types that form vary. The cell types formed were determined by markers expressed in the differentiated cell populations. TE: trophectoderm, Endo: Endoderm, Meso: Mesoderm, Ecto: Ectoderm.
