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. 2009 Oct 7;37(22):7654–7664. doi: 10.1093/nar/gkp779

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Chemical probing of mSP-SL-HIV-1 mRNA complexed with 70 S, tRNA^Met and tRNA^Leu analyzed by primer extension. (A) Left panel: DMS and CMCT (the control lane without DMS or CMCT but in presence of 70 S particles is on the left; right panel: KE. Nucleotides with modified reactivity are highlighted with an arrow. (B) Summary of the chemical modifications in the structure of the frameshift stimulatory signal. The footprint protections observed upon binding of the ribosome are shaded. The nucleotides with increased reactivity are highlighted with a square. Observed toeprints in the pre-translocation complex are indicated by arrows.