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. 2009 Oct 9;37(22):7360–7367. doi: 10.1093/nar/gkp821

Figure 2.

Figure 2.

Melting profile of ∼4000 base pairs around the human RAD50 promoter, viewed using the UCSC genome browser. RAD50 is a homologue of a yeast gene involved in double-stranded break repair. Like many human genes, RAD50 has a CpG island overlapping the first exon. The annotation (RefSeq, HAVANA, CAGE) shows multiple transcription start sites, clustered around the area with the highest melting temperature. The melting profile takes the form of multiple flat domains, due to cooperativity.