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. 2009 Oct 20;37(22):7728–7740. doi: 10.1093/nar/gkp862

Figure 1.

Figure 1.

Chemical structure of Watson–Crick base pairs in DNA and RNA with potential positions for non-invasive fluoro labeling as indicated. While ribose 2′-fluoro labels were evaluated for RNA secondary structure probing previously in our laboratory (42), the present study is focused on a comprehensive comparison of 5-fluoro pyrimidine labeling for both DNA and RNA structure probing by 19F NMR spectroscopy.