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. 2009 Oct 20;37(22):7728–7740. doi: 10.1093/nar/gkp862

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — PreQ₁ sensitive riboswitch aptamer. (A) RNA secondary structure model for ligand-induced folding (49). The 5-fluoro uridine label is positioned in a single-stranded region in the free RNA whereas it is located in a double-helical segment in the ligand-bound form. (B) ¹⁹F NMR spectra before and after addition of preQ₁. (C) Corresponding ¹H NMR spectra. Increase of ligand concentration results in higher population of the aptamer/ligand complex (data not shown). Conditions: 0.6 mM oligonucleotide, 25 mM sodium arsenate buffer, H₂O/D₂O = 9/1, pH 6.5, 298 K.