FIG. 1.

FG-Nups are distributed throughout the NPC. (A) Schematic representation of the eightfold radial symmetry of the NPC, showing key aspects of the NPC architecture. (B) Nup subcomplexes and relative NPC substructural localization. Each box represents a biochemically or functional documented subcomplex (from studies summarized by Alber et al. [3]). S. cerevisiae FG- Nups are depicted on the left side; vertebrates are depicted on the right. The FG-Nups (colored text) are found in discrete subcomplexes and substructural locations. This includes Nups containing predominantly FG (green text), GLFG (blue text), and FXFG (red text) repeats. Select structural, non-FG-Nups are shown in black text.