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Uremic toxins and SLCO4C1 transporter in renal failure. ADMA is formed by protein arginine N-methyltransferase (PRMT) from arginine and degrades to citrulline by DDAH. Note that SLCO4C1 facilitates the excretion of GSA, ADMA, and trans-aconitate and that statins increase the expression and the function of SLCO4C1, resulting in reductions of the uremic toxins and BP. Trans-aconitase inhibits aconitase activity and induces reactive oxygen species (ROS). Aco, aconitase.
